Medscape | Drug Metab Dispos (2024)

Table of Contents

2016 - 44(8)

• Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmaco*kinetics, Safety, and Efficacy of Xenobiotics.

  January 01, 2016

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• VX-509 (Decernotinib)-Mediated CYP3A Time-Dependent Inhibition: An Aldehyde Oxidase Metabolite as a Perpetrator of Drug-Drug Interactions.

  January 01, 2016

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• Biotransformation and Rearrangement of Laromustine.

  January 01, 2016

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• Effects of Chronic Renal Failure on Brain Cytochrome P450 in Rats.

  January 01, 2016

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  Drug Metabolism and DispositionWhat Is A Dispo? - FinanceNInsuranceDrug Metabolism and Disposition Instructions to AuthorsActee Injection Dispo Pack: View Uses, Side Effects, Price and Substitutes | 1mg
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• Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver.

  January 01, 2016

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• Impact of Experimental Conditions on the Evaluation of Interactions between Multidrug and Toxin Extrusion Proteins and Candidate Drugs.

  January 01, 2016

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• Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes.

  January 01, 2016

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• Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.

  January 01, 2016

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• A Pharmaco*kinetic Modeling Approach to Predict the Contribution of Active Metabolites to Human Efficacious Dose.

  January 01, 2016

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• Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

  January 01, 2016

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• Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane.

  January 01, 2016

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• Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs.

  January 01, 2016

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• Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor.

  January 01, 2016

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• Difference in the Pharmaco*kinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.

  January 01, 2016

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• Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds.

  January 01, 2016

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• Recommendation to Exclude Bile-Duct-Cannulated Rats with Hyperbilirubinemia for Proper Conduct of Biliary Drug Excretion Studies.

  January 01, 2016

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• Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.

  January 01, 2016

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• Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways.

  January 01, 2016

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• Metabolism and Disposition of Pan-Genotypic Inhibitor of Hepatitis C Virus NS5A Ombitasvir in Humans.

  January 01, 2016

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• Metabolism and Disposition of the Hepatitis C Protease Inhibitor Paritaprevir in Humans.

  January 01, 2016

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• Metabolism and Disposition of Hepatitis C Polymerase Inhibitor Dasabuvir in Humans.

  January 01, 2016

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• Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.

  January 01, 2016

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• Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA.

  January 01, 2016

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• Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.

  January 01, 2016

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• Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

  January 01, 2016

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• Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.

  January 01, 2016

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• Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.

  January 01, 2016

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• Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.

  January 01, 2016

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• Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.

  January 01, 2016

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• Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

  January 01, 2016

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• Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.

  January 01, 2016

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• Nonclinical Pharmaco*kinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide).

  January 01, 2016

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• Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms.

  January 01, 2016

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